Ankylosing Spondylitis is an autoimmune condition, which typically occurs in young men. The average age of onset of ankylosing spondylitis is between 20 to 40 years old. The typical symptoms are persistent low back pain with stiffness in the morning. Ultimately, the patient will experience decrease range of motion in the back. Ankylosing spondylitis can also cause inflammation in the eye as well as recurrent tendinitis such as Achilles tendinitis or plantar fasciitis. Ankylosing spondylitis is often difficult to diagnose and requires imaging studies and a good rheumatologic physical exam. Blood test are helpful but not required for the diagnosis. Ankylosing spondylitis is often managed with anti-inflammatory agents as well as injectable or intravenous biologic agents.